HOW IT WORKS

Rebinyn® is an extended half-life treatment, which means it works in your body longer to control bleeds. The technology used to extend the half-life of Rebinyn® is called PEGylationa or “PEG” for short.

aPEG=polyethylene glycol.

Leopoldo, who lives with hemophilia B, talks to his friend
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All images of hemophilia B patients shown are for illustrative purposes only.

HOW IT WORKS

Rebinyn® is an extended half-life treatment, which means it works in your body longer to control bleeds. The technology used to extend the half-life of Rebinyn® is called PEGylationa or “PEG” for short.

aPEG=polyethylene glycol.

HOW DOES PEGYLATION WORK?

HOW DOES PEGYLATION WORK?

The PEG molecule is designed to attach to a specific part of Rebinyn®

GlycoPEGylation keeps Rebinyn® in your blood longer to stop bleeding

Rebinyn® releases active FIX similar to human FIX

  • Animals given repeat doses of Rebinyn® showed Polyethylene Glycol (PEG) inside cells lining blood vessels in the choroid plexus, which makes the fluid that cushions the brain. The potential human implications of these animal tests are unknown

WHAT IS HALF-LIFE?

Half-life is the time it takes for the level of factor in the blood to fall by half (50%).

QUESTIONS ABOUT ON-DEMAND TREATMENT?

Jason, who lives with hemophilia B, plays with his dad in a garden

All images of hemophilia B patients shown are for illustrative purposes only.

QUESTIONS ABOUT ON-DEMAND TREATMENT?

Rebinyn® is an on-demand therapy, which means you only take it when bleeds occur. Most bleeds are treated with 1-2 infusions. Treating on-demand means there’s no need to keep to a strict dosing schedule. Rebinyn® is not indicated for prophylaxis use.

For people living with mild, moderate, or severe hemophilia B, the higher factor levels achieved and sustained with Rebinyn® may allow for fewer infusions.b Talk to your doctor to explore whether Rebinyn® is right for you and your lifestyle.

bBased upon treatment guidelines for factor activity levels for different severities of bleeding.

NEW TO REBINYN®?

ORDER A WELCOME KIT.

This kit is designed to help you get started with Rebinyn®. It contains a Quick Start Guide, Infusion Logbook, a calendar, and a tourniquet—all in a zippered carrying bag.

For more information on how to get your Welcome Kit, please contact a Novo Nordisk representative.

Rebinyn® Welcome Kit

For more information on how to get your Welcome Kit, please contact a Novo Nordisk representative.

DESIGNED WITH SAFETY IN MIND

In clinical studies, Rebinyn® was shown to be safe and effective.

3 different Rebinyn® vials with peel off labels

RESOURCES FOR YOU

These materials can help you stay educated on bleeding disorders.

Educational resources for people with bleeding disorders

STAY IN THE KNOW. SIGN UP TO GET THE LATEST UPDATES ON REBINYN®

STAY IN THE KNOW. SIGN UP TO GET THE LATEST UPDATES ON REBINYN®

Selected Important Safety Information

What is the most important information I need to know about Rebinyn®?

  • Do not attempt to do an infusion yourself unless you have been taught how by your healthcare provider or hemophilia treatment center. Carefully follow your healthcare provider’s instructions regarding the dose and schedule for infusing Rebinyn®.

Who should not use Rebinyn®?
Do not use Rebinyn® if you:

  • are allergic to Factor IX or any of the other ingredients of Rebinyn®.
  • are allergic to hamster proteins.
     

Indications and Usage

What is Rebinyn® Coagulation Factor IX (Recombinant), GlycoPEGylated?
Rebinyn® is an injectable medicine used to replace clotting Factor IX that is missing in patients with hemophilia B. Rebinyn® is used to treat and control bleeding in people with hemophilia B. Your healthcare provider may give you Rebinyn® when you have surgery. Rebinyn® is not used for routine prophylaxis or for immune tolerance therapy.
 

Important Safety Information

What is the most important information I need to know about Rebinyn®?

  • Do not attempt to do an infusion yourself unless you have been taught how by your healthcare provider or hemophilia treatment center. Carefully follow your healthcare provider’s instructions regarding the dose and schedule for infusing Rebinyn®.

Who should not use Rebinyn®?
Do not use Rebinyn® if you:

  • are allergic to Factor IX or any of the other ingredients of Rebinyn®.
  • are allergic to hamster proteins.

What should I tell my healthcare provider before using Rebinyn®?
Tell your healthcare provider if you:

  • have or have had any medical conditions.
  • take any medicines, including non-prescription medicines and dietary supplements.
  • are nursing, pregnant, or plan to become pregnant.
  • have been told you have inhibitors to Factor IX.

How should I use Rebinyn®?

  • Rebinyn® is given as an infusion into the vein.
  • Call your healthcare provider right away if your bleeding does not stop after taking Rebinyn®.
  • Do not stop using Rebinyn® without consulting your healthcare provider.

What are the possible side effects of Rebinyn®?

  • Common side effects include swelling, pain, rash or redness at the location of the infusion, and itching.
  • Call your healthcare provider right away or get emergency treatment right away if you get any of the following signs of an allergic reaction: hives, chest tightness, wheezing, difficulty breathing, and/or swelling of the face.
  • Tell your healthcare provider about any side effect that bothers you or that does not go away.
  • Animals given repeat doses of Rebinyn® showed Polyethylene Glycol (PEG) inside cells lining blood vessels in the choroid plexus, which makes the fluid that cushions the brain. The potential human implications of these animal tests are unknown.
     

Please click here for Prescribing Information.

Rebinyn® is a prescription medication.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.